Opioid dependence is a disorder of regulation of opioid use arising from repeated or continuous use of opioids. What makes the topic so challenging is that opioids are beneficial for those with chronic pain. While most people prescribed drugs drug addiction like oxycodone will use them responsibly, many will develop opioid use disorder (OUD).

  • Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
  • As an opioid, OXYCONTIN exposes users to the risks of addiction, abuse, and misuse.
  • Your doctor may want you to gradually reduce the amount you are using before stopping it completely.
  • The most common cause of an oxycodone overdose is taking too much of the drug at once.

Evaluate Signs and Symptoms

In patients already receiving an opioid analgesic, prescribe a lower initial dose of the benzodiazepine or other CNS depressant than indicated in the absence of an opioid, and titrate based on clinical response. If an opioid analgesic is initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe a lower initial dose of the opioid analgesic, and titrate based on clinical response. Inform patients and caregivers of this potential interaction and educate them on the signs and symptoms of respiratory depression (including sedation).

What Drugs, Substances, or Supplements Interact with OxyContin?

oxycontin overdose

Advise patients to seek medical attention if they experience symptoms of hyperalgesia, including worsening pain, increased sensitivity to pain, or https://ecosoberhouse.com/ new pain see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS. Discuss with the patient and caregiver the availability of naloxone for the emergency treatment of opioid overdose, both when initiating and renewing treatment with OXYCONTIN. Inform patients of the risk of life-threatening respiratory depression, including information that the risk is greatest when starting OXYCONTIN or when the dosage is increased, and that it can occur even at recommended dosages. OXYCONTIN may cause severe hypotension, including orthostatic hypotension and syncope in ambulatory patients.

oxycontin overdose

Patient Counseling Information

Although certain medicines should not why is oxy so addictive be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

  • Oxycodone binding to plasma protein at 37°C and a pH of 7.4 was about 45%.
  • In the case of highly-potent opioid drugs like oxycodone, high doses can be extremely lethal.
  • In addition, low concentrations of Oxycontin have been found in breast milk.
  • Misuse means taking a medicine in a way other than how it was prescribed.
  • Educate patients and caregivers on how to recognize respiratory depression and emphasize the importance of calling 911 or getting emergency medical help, even if naloxone is administered.

Your assessment results are confidential.

You are encouraged to report negative side effects of prescription drugs to the FDA. The plasma concentrations of oxycodone are only nominally affected by age, being 15% greater in elderly as compared to young subjects (age 21-45). Following intravenous administration, the steady-state volume of distribution (Vss) for oxycodone was 2.6 L/kg. Oxycodone binding to plasma protein at 37°C and a pH of 7.4 was about 45%. Once absorbed, oxycodone is distributed to skeletal muscle, liver, intestinal tract, lungs, spleen, and brain. Oxycodone has been found in breast milk see Use In Specific Populations.